Absence of endogenous circadian rhythmicity in blood pressure?

被引:74
作者
Kerkhof, GA [1 ]
Van Dongen, HPA [1 ]
Bobbert, AC [1 ]
机构
[1] Leiden Univ, Dept Physiol, NL-2300 RC Leiden, Netherlands
关键词
blood pressure; heart rate; circadian rhythm; constant-routine;
D O I
10.1016/S0895-7061(97)00461-5
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Currently available evidence reveals a predominant role of exogenous (so-called "masking") factors in the 24 h variation of blood pressure in humans. The existence of a (minor) endogenous circadian factor cannot be excluded, however. This possibility was tested by applying the rigorous unmasking conditions of the constant-routine protocol, that is, strict bed rest in a separate bedroom, total sleep deprivation, constant ambient temperature and illumination, and hourly equicaloric food and liquid intake. Twenty-five normotensive young individuals were subjected to a 26 h constant-routine procedure while hourly measurements were made of their blood pressure and heart rate. Repeated-measures analysis of variance failed to show a significant 24 h variation of blood pressure. The power of this test appeared satisfactorily high (>0.95). Heart rate, however, exhibited a significant circadian pattern, with a range of 6.7 beats/min (10% of the 24 h mean value). Moreover, the timing of the 24 h heart rate curves differed significantly between so-called morning (n = 10) and evening (n = 9) individuals. Mean peak values for the morning-types occurred at 11 AM, for the evening types nearly 6 h later. In conclusion, no evidence was found for the involvement of a circadian oscillator in the regulation of blood pressure. (C) 1998 American Journal of Hypertension, Ltd.
引用
收藏
页码:373 / 377
页数:5
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