Interleukin-6: minor player or starring role in the development of hormone-refractory prostate cancer?

被引：40

作者：

Corcoran, NM

Costello, AJ

机构：

[1] Royal Melbourne Hosp, Dept Urol, Melbourne, Vic 3050, Australia

[2] Univ Melbourne, Parkville, Vic 3052, Australia

来源：

BJU INTERNATIONAL | 2003年 / 91卷 / 06期

关键词：

D O I：

10.1046/j.1464-410X.2003.04025.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Tumour growth independent of the presence of androgens represents the main challenge in the treatment of prostate cancer. The concept that other factors activate the normal or mutated androgen receptor has been given new significance with the identification of interleukin- 6. The review by Corcoran et al. is timely, and updates the reader on current publications and understanding of the role of interleukin-6 in activating the androgen receptor and in the progression of prostate cancer. This will be helpful, as the number of publication in this area increases; in fact, five papers have already been published since this review was accepted.

引用

页码：545 / 553

页数：9

共 79 条

[71] Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways [J].