Application of MALDI Mass Spectrometry in Natural Products Analysis

被引：28

作者：

Silva, Ricardo ^{[1
]}

Lopes, Norberto Peporine ^{[1
]}

Silva, Denise Brentan ^{[1
,2
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, NPPNS, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP, Brazil

[2] Univ Fed Mato Grosso Sul UFMS, CCBS, Lab Prod Nat & Espectrometria Massas LAPNEM, Ave Costa & Silva S-N, BR-79070900 Campo Grande, MS, Brazil

来源：

PLANTA MEDICA | 2016年 / 82卷 / 08期

关键词：

MALDI; dereplication; natural products; fragmentation; data processing; LASER-DESORPTION/IONIZATION-TIME; POST-SOURCE-DECAY; TOF MS ANALYSIS; DESORPTION IONIZATION MALDI; THIN-LAYER-CHROMATOGRAPHY; FATTY-ACID ESTERS; ARABIDOPSIS-THALIANA; SMALL MOLECULES; QUANTITATIVE-ANALYSIS; HYDROLYZABLE TANNINS;

D O I：

10.1055/s-0042-104800

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This article presents the utility of mass spectrometry with a MALDI ionization source in natural products analysis. The advantages and drawbacks of this technique for natural products analyses will be presented and discussed. In addition, the structural determination of secondary metabolites using MALDI-MS/MS will be explored, which can guide MALDI experimental methods and stimulate new research in this area. Finally, several important approaches for MALDI data processing will be discussed.

引用

收藏

页码：671 / 689

页数：19

相关论文

共 235 条

[11] Structural Elucidation of Novel Saponins in the Sea Cucumber Holothuria lessoni [J].

Bahrami, Yadollah ;

Zhang, Wei ;

Chataway, Tim ;

Franco, Chris .

MARINE DRUGS, 2014, 12 (08) :4439-4473

[12] Discovery of Novel Saponins from the Viscera of the Sea Cucumber Holothuria lessoni [J].

Bahrami, Yadollah ;

Zhang, Wei ;

Franco, Chris .

MARINE DRUGS, 2014, 12 (05) :2633-2667

[13] MALDI imaging mass spectrometry for direct tissue analysis: technological advancements and recent applications [J].

Balluff, Benjamin ;

Schoene, Cedrik ;

Hoefler, Heinz ;

Walch, Axel .

HISTOCHEMISTRY AND CELL BIOLOGY, 2011, 136 (03) :227-244

[14] MALDI-TOF mass spectrometry and PSD fragmentation as means for the analysis of condensed tannins in plant leaves and needles [J].

Behrens, A ;

Maie, N ;

Knicker, H ;

Kögel-Knabner, I .

PHYTOCHEMISTRY, 2003, 62 (07) :1159-1170

[15] Characterization of gallotannins and benzophenone derivatives from mango (Mangifera indica L. cv. 'Tommy Atkins') peels, pulp and kernels by high-performance liquid chromatography electrospray ionization mass spectrometry [J].

Berardini, N ;

Carle, R ;

Schieber, A .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2004, 18 (19) :2208-2216

[16] A comprehensive high-resolution mass spectrometry approach for characterization of metabolites by combination of ambient ionization, chromatography and imaging methods [J].

Berisha, Arton ;

Dold, Sebastian ;

Guenther, Sabine ;

Desbenoit, Nicolas ;

Takats, Zoltan ;

Spengler, Bernhard ;

Roempp, Andreas .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2014, 28 (16) :1779-1791

[17] Ion sources for mass spectrometric identification and imaging of molecular species [J].

Bhardwaj, Chhavi ;

Hanley, Luke .

NATURAL PRODUCT REPORTS, 2014, 31 (06) :756-767

[18]

Bier M. E., 2010, ELECTROSPRAY MALDI M, P265

[19] Mass spectrometry imaging of plant metabolites - principles and possibilities [J].

Bjarnholt, Nanna ;

Li, Bin ;

D'Alvise, Janina ;

Janfelt, Christian .

NATURAL PRODUCT REPORTS, 2014, 31 (06) :818-837

[20] Warping methods for spectroscopic and chromatographic signal alignment: A tutorial [J].

Bloemberg, Tom G. ;

Gerretzen, Jan ;

Lunshof, Anton ;

Wehrens, Ron ;

Buydens, Lutgarde M. C. .

ANALYTICA CHIMICA ACTA, 2013, 781 :14-32

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