Selective nuclear export of viral mRNAs in influenza-virus-infected cells

被引：39

作者：

Chen, ZY ^{[1
]}

Krug, RM ^{[1
]}

机构：

[1] Univ Texas, Inst Cellular & Mol Biol, Sect Mol Genet & Microbiol, Austin, TX 78712 USA

来源：

TRENDS IN MICROBIOLOGY | 2000年 / 8卷 / 08期

关键词：

D O I：

10.1016/S0966-842X(00)01794-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The NS1A protein of influenza A virus specifically inhibits the cellular machinery that processes the 3' ends of cellular pre-mRNAs by targeting two of the essential proteins of this machinery. Because the virus does not use this cellular machinery to synthesize the 3' poly(A) ends of viral mRNA, the nuclear export of cellular but not viral mRNAs is selectively inhibited.

引用

页码：376 / 383

页数：10

共 59 条

[1] REGULATION OF THE EXTENT OF SPLICING OF INFLUENZA-VIRUS NS1 MESSENGER-RNA - ROLE OF THE RATES OF SPLICING AND OF THE NUCLEOCYTOPLASMIC TRANSPORT OF NS1 MESSENGER-RNA [J].

ALONSOCAPLEN, FV ;

KRUG, RM .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (02) :1092-1098

[2] NUCLEOCYTOPLASMIC TRANSPORT - THE INFLUENZA-VIRUS NS1 PROTEIN REGULATES THE TRANSPORT OF SPLICED NS2 MESSENGER-RNA AND ITS PRECURSOR NS1 MESSENGER-RNA [J].

ALONSOCAPLEN, FV ;

NEMEROFF, ME ;

YUN, Q ;

KRUG, RM .

GENES & DEVELOPMENT, 1992, 6 (02) :255-267

[3] Last but not least: Regulated poly(A) tail formation [J].

Barabino, SML ;

Keller, W .

CELL, 1999, 99 (01) :9-11

[4] The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins [J].

Barabino, SML ;

Hubner, W ;

Jenny, A ;

MinvielleSebastia, L ;

Keller, W .

GENES & DEVELOPMENT, 1997, 11 (13) :1703-1716

[5] DEGRADATION OF CELLULAR MESSENGER-RNA DURING INFLUENZA-VIRUS INFECTION - ITS POSSIBLE ROLE IN PROTEIN-SYNTHESIS SHUTOFF [J].

BELOSO, A ;

MARTINEZ, C ;

VALCARCEL, J ;

SANTAREN, JF ;

ORTIN, J .

JOURNAL OF GENERAL VIROLOGY, 1992, 73 :575-581

[6] ASSEMBLY OF A PROCESSIVE MESSENGER-RNA POLYADENYLATION COMPLEX [J].

BIENROTH, S ;

KELLER, W ;

WAHLE, E .

EMBO JOURNAL, 1993, 12 (02) :585-594

[7] Deciphering the cellular pathway for transport of poly(A)-binding protein II [J].

Calado, A ;

Kutay, U ;

Kühn, U ;

Wahle, E ;

Carmo-Fonseca, M .

RNA, 2000, 6 (02) :245-256

[8] Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3′-end processing machinery [J].

Chen, ZY ;

Li, YZ ;

Krug, RM .

EMBO JOURNAL, 1999, 18 (08) :2273-2283

[9] A novel RNA-binding motif in influenza A virus non-structural protein 1 [J].

Chien, CY ;

Tejero, R ;

Huang, YP ;

Zimmerman, DE ;

Rios, CB ;

Krug, RM ;

Montelione, GT .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (11) :891-895

[10] MATURE MESSENGER-RNA 3' END FORMATION STIMULATES RNA EXPORT FROM THE NUCLEUS [J].

ECKNER, R ;

ELLMEIER, W ;

BIRNSTIEL, ML .

EMBO JOURNAL, 1991, 10 (11) :3513-3522

← 1 2 3 4 5 6 →