Urinary kidney injury biomarkers and urine creatinine normalization: a false premise or not?

被引：39

作者：

Goldstein, Stuart L. ^{[1
,2
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Ctr Acute Care Nephrol, Cincinnati, OH 45229 USA

[2] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA

来源：

KIDNEY INTERNATIONAL | 2010年 / 78卷 / 05期

关键词：

MARKER;

D O I：

10.1038/ki.2010.200

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Substantial research has focused on the discovery of urinary biomarkers to detect acute kidney injury (AKI) before a rise in serum creatinine. As in chronic kidney diseases, the concentrations of urinary AKI biomarkers have been normalized to urine creatinine concentration to account for creatinine clearance and urine flow. Waikar et al. challenge the assumption that normalization to creatinine clearance in a chronic disease state can be extrapolated to an acute state, in which creatinine clearance is, by definition, changing acutely. Kidney International (2010) 78, 433-435. doi:10.1038/ki.2010.200

引用

页码：433 / 435

页数：3

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