Application and interpretation of FISH in biomarker studies

被引：14

作者：

Bayani, Jane

Squire, Jeremy A.

机构：

[1] Princess Margaret Hosp, Univ Hlth Network, Div Appl Mol Oncol, Toronto, ON M5G 2M9, Canada

[2] Univ Toronto, Ontario Canc Inst, Princess Margaret Hosp, Univ Hlth Network,Dept Lab Med & Pathobiol, Toronto, ON M5G 2M9, Canada

[3] Univ Toronto, Ontario Canc Inst, Princess Margaret Hosp, Univ Hlth Network,Dept Med Biophys, Toronto, ON M5G 2M9, Canada

来源：

CANCER LETTERS | 2007年 / 249卷 / 01期

关键词：

chromosomes; cancer genes; arrays;

D O I：

10.1016/j.canlet.2006.12.030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Emerging genomic and proteomic data is creating new opportunities to identify novel biomarkers that will have pathway-specific therapeutic impact on cancer progression. Molecular cytogenetic and fluorescence in situ hybridization (FISH) methods have been primarily used in discovery genetic research laboratories until recently. New automated analytical platforms based on FISH technologies and tissue microarray methods are providing a rapid means to determine the impact of consistent genomic aberrations in clinical trials, and in studies designed to investigate differential chemotherapeutic response. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：97 / 109

页数：13

共 106 条

[31] Morphological spot counting from stacked images for automated analysis of gene copy numbers by fluorescence in situ hybridization [J].