Matrix metalloproteinases and tissue inhibitors of metalloproteinases - Structure, function, and biochemistry

被引：3670

作者：

Visse, R ^{[1
]}

Nagase, H ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Rheumatol, Kennedy Inst, London W6 8LH, England

来源：

CIRCULATION RESEARCH | 2003年 / 92卷 / 08期

关键词：

extracellular matrix; protease; protease inhibitors;

D O I：

10.1161/01.RES.0000070112.80711.3D

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Matrix metalloproteinases ( MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration. Currently 23 MMP genes have been identified in humans, and most are multidomain proteins. This review describes the members of the matrixin family and discusses substrate specificity, domain structure and function, the activation of proMMPs, the regulation of matrixin activity by tissue inhibitors of metalloproteinases, and their pathophysiological implication.

引用

收藏

页码：827 / 839

页数：13

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