Matrix metalloproteinase inhibitors and cancer

被引：9

作者：

Lauer-Fields, JL ^{[1
]}

Fields, GB ^{[1
]}

机构：

[1] Florida Atlantic Univ, Dept Chem & Biochem, Boca Raton, FL 33431 USA

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2000年 / 10卷 / 12期

关键词：

cancer; enzyme inhibitors; hydroxamic acids; matrix metalloproteinases; therapeutics;

D O I：

10.1517/13543776.10.12.1873

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The matrix metalloproteinase (MMP) family plays an integral role in both normal and pathological connective tissue remodeling. The accelerated local turnover of the extracellular matrix is often found in tumour cell invasion and metastasis. The development of MMP inhibitors thus offers a promising strategy to modulate metastasis. This review describes developments in MMP inhibitor research and patents related to cancer since 1998.

引用

页码：1873 / 1884

页数：12

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