Mycoplasma fermentans interaction with monocytes/macrophages:: molecular basis

被引：27

作者：

Rawadi, G ^{[1
]}

机构：

[1] Hoechst Marion Roussel, F-93230 Romainville, France

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 08期

关键词：

Mycoplasma; lipoproteins; monocytes; macrophages; mitogen-activated protein kinase (MAPK); toll-like receptor 2 (TLR-2);

D O I：

10.1016/S1286-4579(00)00395-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mycoplasmas are the smallest free-living self-replicating bacteria - having diameters of 200 to 800 nm - widely distributed in animals and plants. Mycoplasma fermentans is a human pathogen suspected to be involved in the progression of autoimmune diseases. Although pathogenesis mechanisms of M. fermentans are currently poorly understood, the role of these microorganisms as immunomodulatory agents is well established. In the present paper, we will review and discuss recent breakthroughs in the field. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：955 / 964

页数：10

共 44 条

[41] Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2-and MyD88-dependent signaling pathway [J].