Structure of the first parallel DNA quadruplex-drug complex

被引：197

作者：

Clark, GR ^{[1
]}

Pytel, PD

Squire, CJ

Neidle, S

机构：

[1] Univ Auckland, Dept Chem, Auckland 1, New Zealand

[2] Univ London, Sch Pharm, Canc Res UK Biomol Struct Grp, London WC1N 1AX, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 14期

关键词：

D O I：

10.1021/ja0297988

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5′ end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin. Copyright © 2003 American Chemical Society.

引用

收藏

页码：4066 / 4067

页数：2

相关论文

共 33 条

[21] Crystal structure of parallel quadruplexes from human telomeric DNA [J].

Parkinson, GN ;

Lee, MPH ;

Neidle, S .

NATURE, 2002, 417 (6891) :876-880

[22] The crystal structure of a parallel-stranded guanine tetraplex at 0.95 angstrom resolution [J].

Phillips, K ;

Dauter, Z ;

Murchie, AIH ;

Lilley, DMJ ;

Luisi, B .

JOURNAL OF MOLECULAR BIOLOGY, 1997, 273 (01) :171-182

[23] Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors [J].

Read, M ;

Harrison, RJ ;

Romagnoli, B ;

Tanious, FA ;

Gowan, SH ;

Reszka, AP ;

Wilson, WD ;

Kelland, LR ;

Neidle, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (09) :4844-4849

[24] Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: Structure-activity relationships [J].

Read, MA ;

Wood, AA ;

Harrison, JR ;

Gowan, SM ;

Kelland, LR ;

Dosanjh, HS ;

Neidle, S .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (22) :4538-4546

[25] Structural characterization of a guanine-quadruplex ligand complex [J].

Read, MA ;

Neidle, S .

BIOCHEMISTRY, 2000, 39 (44) :13422-13432

[26] Sequence and structural selectivity of nucleic acid binding ligands [J].

Ren, JS ;

Chaires, JB .

BIOCHEMISTRY, 1999, 38 (49) :16067-16075

[27] Telomeres and telomerases as drug targets [J].

Rezler, EM ;

Bearss, DJ ;

Hurley, LH .

CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (04) :415-423

[28] Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands [J].

Riou, JF ;

Guittat, L ;

Mailliet, P ;

Laoui, A ;

Renou, E ;

Petitgenet, O ;

Mégnin-Chanet, F ;

Hélène, C ;

Mergny, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (05) :2672-2677

[29] The effect of sodium, potassium and ammonium ions on the conformation of the dimeric quadruplex formed by the Oxytricha nova telomere repeat oligonucleotide d(G4T4G4) [J].

Schultze, P ;

Hud, NV ;

Smith, FW ;

Feigon, J .

NUCLEIC ACIDS RESEARCH, 1999, 27 (15) :3018-3028

[30] Quadruplex-interactive agents as telomerase inhibitors: Synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase [J].

Shi, DF ;

Wheelhouse, RT ;

Sun, DY ;

Hurley, LH .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (26) :4509-4523

← 1 2 3 4 →