Highly enantioselective reductive amination of simple aryl ketones catalyzed by Ir-f-Binaphane in the presence of titanium(IV) isopropoxide and iodine

被引：159

作者：

Chi, YX ^{[1
]}

Zhou, YG ^{[1
]}

Zhang, XM ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 10期

关键词：

D O I：

10.1021/jo026856z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using an Ir-f-Binaphane complex as the catalyst, complete conversions and high enantioselectivies (up to 96% ee) were achieved in the asymmetric reductive amination of aryl ketones in the presence of Ti((OPr)-Pr-i)(4) and I-2. A simple and efficient method of synthesizing chiral primary amines has been realized.

引用

页码：4120 / 4122

页数：3

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