The application of Ir-complexes of trans-2,5-dialkylpyrrolidinyl-benzyldiphenylphosphines to the enantioselective reduction of imines

被引：28

作者：

Cahill, JP

Lightfoot, AP

Goddard, R

Rust, J

Guiry, PJ ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Dublin, Dept Chem, Dublin 4, Ireland

[2] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(98)00451-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation of iridium (COD) complexes of phosphinamine ligands possessing an enantiopure trans-2,5-dialkylpyrrolidinyl unit is described. These complexes were successfully applied to the enantioselective reduction of test substrate imines in excellent conversions with enantioselectivities of up to 52% ee. In attempts to optimize reaction conditions the catalyst loading, time, and hydrogen pressure were varied. X-Ray crystal structures of the iridium (COD) tetrafluoroborate complexes 5 and 6 are discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：4307 / 4312

页数：6

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