The application of Pd-complexes of trans-2,5-dialkylpyrrolidinyl-benzyldiphenylphosphines to enantioselective allylic alkylation

被引：41

作者：

Cahill, JP ^{[1
]}

Guiry, PJ ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Dublin, Dept Chem, Dublin 4, Ireland

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(98)00425-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation of cationic palladium (eta(3)-C3H5) complexes 6 and 7, possessing an enantiopure trans-2,5-dialkylpyrrolidinyl unit, is described. These complexes were applied to the enantioselective alkylation of the test substrate, 1,3-diphenylpropenyl acetate 8, with dimethyl malonate in good to high conversions with enantioselectivities of up to 90% ee for the 2,5-diethylpyrrolidinyl substituted complex 7. Attempts to optimise reaction conditions included variation of solvent and temperature and the source of the malonate nucleophile. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4301 / 4305

页数：5

共 41 条

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