Detection of the interleukin 18 family in rat brain by RT-PCR

被引：56

作者：

Wheeler, RD

Culhane, AC

Hall, MD

Pickering-Brown, S

Rothwell, NJ

Luheshi, GN

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[2] Parke Davis Neurosci Res Ctr, Cambridge, England

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 77卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

interleukin; 18; AcPL; binding protein; hypothalamus; RT-PCR;

D O I：

10.1016/S0169-328X(00)00069-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin 18, an inflammatory cytokine, mediates its effects by interaction with its receptor complex, consisting of the IL-18 receptor (IL-18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL-18 binding protein (IL-18BF), has been identified recently. This study reports the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in the brain of normal adult rats using RT-PCR. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：290 / 293

页数：4

共 26 条

[1] Cloning and expression of interleukin-18 binding protein [J].

Aizawa, Y ;

Akita, K ;

Taniai, M ;

Torigoe, K ;

Mori, T ;

Nishida, Y ;

Ushio, S ;

Nukada, Y ;

Tanimoto, T ;

Ikegami, H ;

Ikeda, M ;

Kurimoto, M .

FEBS LETTERS, 1999, 445 (2-3) :338-342

[2] Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling [J].

Born, TL ;

Thomassen, E ;

Bird, TA ;

Sims, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (45) :29445-29450

[3]

Conti B, 1997, J BIOL CHEM, V272, P2035

[4] Cultures of astrocytes and microglia express interleukin 18 [J].

Conti, B ;

Park, LCH ;

Calingasan, NY ;

Kim, Y ;

Kim, H ;

Bae, Y ;

Gibson, GE ;

Joh, TH .

MOLECULAR BRAIN RESEARCH, 1999, 67 (01) :46-52

[5] Cloning of rat brain interleukin-18 cDNA [J].

Culhane, AC ;

Hall, MD ;

Rothwell, NJ ;

Luheshi, GN .

MOLECULAR PSYCHIATRY, 1998, 3 (04) :362-366

[6] Interferon-γ-inducing factor (IL-18) and interferon-γ in inflammatory CNS diseases [J].

Fassbender, K ;

Mielke, O ;

Bertsch, T ;

Muehlhauser, F ;

Hennerici, M ;

Kurimoto, M ;

Rossol, S .

NEUROLOGY, 1999, 53 (05) :1104-1106

[7]

Fehniger TA, 1999, J IMMUNOL, V162, P4511

[8] Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production [J].

Ghayur, T ;

Banerjee, S ;

Hugunin, M ;

Butler, D ;

Herzog, L ;

Carter, A ;

Quintal, L ;

Sekut, L ;

Talanian, R ;

Paskind, M ;

Wong, W ;

Kamen, R ;

Tracey, D ;

Allen, H .

NATURE, 1997, 386 (6625) :619-623

[9] Activation of interferon-gamma inducing factor mediated by interleukin-1 beta converting enzyme [J].

Gu, Y ;

Kuida, K ;

Tsutsui, H ;

Ku, G ;

Hsiao, K ;

Fleming, MA ;

Hayashi, N ;

Higashino, K ;

Okamura, H ;

Nakanishi, K ;

Kurimoto, M ;

Tanimoto, T ;

Flavell, RA ;

Sato, V ;

Harding, MW ;

Livingston, DJ ;

Su, MSS .

SCIENCE, 1997, 275 (5297) :206-209

[10] Quantification of human interleukin 18 mRNA expression by competitive reverse transcriptase polymerase chain reaction [J].

Klein, SA ;

Ottmann, OG ;

Ballas, K ;

Dobmeyer, TS ;

Pape, M ;

Weidmann, E ;

Hoelzer, D ;

Kalina, U .

CYTOKINE, 1999, 11 (06) :451-458

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