Epidemiology of osteoporotic fractures in Europe: Towards biologic mechanisms - The European Prospective Osteoporosis Study

被引：7

作者：

Reeve, J

Silman, A

机构：

[1] Univ Cambridge, Dept Med, Cambridge CB2 2SR, England

[2] Inst Publ Hlth, Cambridge, England

[3] Univ Manchester, ARC Epidemiol Res Unit, Manchester, Lancs, England

来源：

OSTEOPOROSIS INTERNATIONAL | 1997年 / 7卷 / Suppl 3期

关键词：

D O I：

10.1007/BF03194348

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The EVOS study has been an extremely fertile source of ideas and has tended to support a number of hypotheses concerning the importance of physical activity, trauma, sex hormone status, alcohol consumption and, above, all relative body weight (expressed as BMI) as direct or indirect determinants of incident vertebral fractures. However, a prevalence study cannot establish how many deformities were due to osteoporosis nor when they occurred. The forthcoming results of the EPOS vertebral incidence study will allow most or all of these ideas to be tested. With measurements of bone density, biomarkers and even bone histology [30] in some subjects EPOS should be well equipped to address questions relating risk factors for fracture to postulated biological mechanisms.

引用

页码：78 / 83

页数：6

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