A simple HPLC-UV method for the assay of ginkgolic acids in Ginkgo biloba extracts

被引：48

作者：

Fuzzati, N ^{[1
]}

Pace, R ^{[1
]}

Villa, E ^{[1
]}

机构：

[1] R&D Labs, Indena SPA, I-20090 Milan, Italy

来源：

FITOTERAPIA | 2003年 / 74卷 / 03期

关键词：

Ginkgo biloba; ginkgolic acids; HPLC-UV; HPLC-APCI-MS;

D O I：

10.1016/S0367-326X(03)00040-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Extracts from the leaves of Ginkgo biloba are among the most widely used phytotherapeutics. Some alkylphenols (ginkgolic acids, cardanols and cardols) have been described as potentially hazardous constituents in Ginkgo extracts. Accordingly, a requirement for a maximum concentration of ginkgolic acids has been proposed in the UE and US pharmacopoeias Ginkgo monographs establishing a limit value of 5 ppm. A novel HPLC-UV method, developed by the use of HPLC-APCI-MS HPLC-DAD techniques and allowing the identification of ginkgolic acids and related phenols, is described. The new analytical method, not requiring enrichment procedures, can be used for the quantification of ginkgolic acids in Ginkgo extracts. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：247 / 256

页数：10

共 16 条

[1]

Grunwald J., 1995, HERBALGRAM, V34, P60

[2] High-performance liquid chromatography-electrospray ionization-mass spectrometry study of ginkgolic acid in the leaves and fruits of the ginkgo tree (Ginkgo biloba) [J].