Normal distribution of apolipoprotein E alleles in progressive supranuclear palsy

被引：24

作者：

Anouti, A

Schmidt, K

Lyons, KE

Hubble, JP

Schellenberg, G

Golbe, LI

Lang, AE

GalvezJimenez, N

Hershey, L

Koller, WC

机构：

[1] UNIV KANSAS,MED CTR,DEPT NEUROL,KANSAS CITY,KS 66160

[2] VET AFFAIRS MED CTR,GERONTOL RES EDUC & CLIN CTR,SEATTLE,WA 98108

[3] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT NEUROL,NEW BRUNSWICK,NJ 08903

[4] TORONTO HOSP,DIV NEUROL,TORONTO,ON M5T 2S8,CANADA

[5] VET AFFAIRS MED CTR,NEUROL SERV,BUFFALO,NY

来源：

NEUROLOGY | 1996年 / 46卷 / 04期

关键词：

D O I：

10.1212/WNL.46.4.1156

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Apolipoprotein E (Apo E) genotype is a genetic risk factor influencing the development of Alzheimer's disease (AD). Progressive supranuclear palsy (PSP), like AD, is a dementing illness with neurofibrillary tangles. We determined the frequencies of Apo E alleles in 52 PSP patients and 52 age- and gender-matched controls. The distribution of Apo E allele frequencies and genotypes showed no difference between PSP and controls. Apo E allele status does not influence the development of PSP.

引用

页码：1156 / 1157

页数：2

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