Expression of CD94-NKG2A inhibitory receptor is restricted to a subset of CD8+ T cells

被引：51

作者：

Braud, VM ^{[1
]}

Aldemir, H ^{[1
]}

Breart, B ^{[1
]}

Ferlin, WG ^{[1
]}

机构：

[1] CNRS, Inst Pharmacol Mol & Cellulaire, F-06560 Sophia Antipolis, France

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 04期

关键词：

D O I：

10.1016/S1471-4906(03)00064-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK)-cell receptors (NKRs) on CD8(+) T cells can modulate antigen-specific T-cell activity but their function and rules that govern their expression remain unclear. Recent work has provided new insight into CD94-NKG2A expression on T cells. Whereas upregulation on the cell surface is induced following T-cell receptor (TCR) engagement, commitment to CD94-NKG2A expression is a clonal attribute. NKRs can therefore shape cytotoxic T-lymphocyte (CTL) responses and should be considered in designing vaccine therapies.

引用

页码：162 / 164

页数：3

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