Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell

被引:1086
作者
Tyson, JJ [1 ]
Chen, KC
Novak, B
机构
[1] Virginia Polytech Inst & State Univ, Dept Biol, Blacksburg, VA 24061 USA
[2] Hungarian Acad Sci, Mol Network Dynam Res Grp, H-1051 Budapest, Hungary
[3] Budapest Univ Technol & Econ, Dept Agr Chem Technol, H-1521 Budapest, Hungary
关键词
D O I
10.1016/S0955-0674(03)00017-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The physiological responses of cells to external and internal stimuli are governed by genes and proteins interacting in complex networks whose dynamical properties are impossible to understand by intuitive reasoning alone. Recent advances by theoretical biologists have demonstrated that molecular regulatory networks can be accurately modeled in mathematical terms, These models shed light on the design principles of biological control systems and make predictions that have been verified experimentally.
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页码:221 / 231
页数:11
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