Effect of inactivated poliovirus vaccine on the antibody response to Bordetella pertussis antigens when combined with diphtheria-pertussis-tetanus vaccine

被引:19
作者
Halperin, SA
Langley, JM
Eastwood, BJ
机构
[1] DALHOUSIE UNIV,DEPT PEDIAT,HALIFAX,NS,CANADA
[2] DALHOUSIE UNIV,DEPT MICROBIOL & IMMUNOL,HALIFAX,NS,CANADA
[3] DALHOUSIE UNIV,DEPT EPIDEMIOL & COMMUNITY HLTH,HALIFAX,NS,CANADA
关键词
D O I
10.1093/clinids/22.1.59
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To determine if inactivated poliovirus vaccine combined with diphtheria and tetanus toxoids and whole-cell pertussis vaccine interferes with the immunogenicity of pertussis vaccine, we performed a randomized trial of diphtheria and tetanus toxoids and pertussis vaccine combined with inactivated poliovirus vaccine given as a single injection or as two separate injections at the same visit to infants immunized at 2, 4, and 6 months of age. A total of 84 infants were enrolled in the study; 44 received the single injection, and 40 received separate injections. Before immunization, there were no differences in antibody values between the two groups. After two vaccine doses, infants immunized with the single injection had significantly lower values of antibody to filamentous hemagglutinin (8.3 vs. 23.7 ELISA units; P < .001), fimbriae (266.5 vs. 771.8 ELISA units; P < 0.01), and the 69-kD membrane protein (442.2 vs. 1,352 ELISA units; P < .001). After the third dose, these differences persisted, and differences were also detected for antibody to pertussis toxin (10.0 vs. 35.5 ELISA units; P < .001) and a whole-bacteria antigen preparation (2,667 vs. 3,829 ELISA units; P < .05). We conclude that there is a diminished antibody response to the pertussis vaccine when inactivated poliovirus vaccine is combined with the diphtheria and tetanus toxoids and pertussis vaccine.
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页码:59 / 62
页数:4
相关论文
共 15 条
[1]   ANTIBODY-RESPONSE TO BORDETELLA-PERTUSSIS ANTIGENS AFTER IMMUNIZATION WITH AMERICAN AND CANADIAN WHOLE-CELL VACCINES [J].
BAKER, JD ;
HALPERIN, SA ;
EDWARDS, K ;
MILLER, B ;
DECKER, M ;
STEPHENS, D .
JOURNAL OF PEDIATRICS, 1992, 121 (04) :523-527
[2]  
BARRETT CD, 1962, PEDIATRICS, V30, P720
[3]   POLIOMYELITIS COMPONENT IN QUADRUPLE ANTIGEN - CONTROLLED CLINICAL STUDY OF ENHANCED RESPONSE OF CHILDREN [J].
BORDT, DE ;
WHALEN, JW ;
BOYER, PA ;
PURSELL, AR ;
STAFFIERI, FP .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1960, 174 (09) :1166-1169
[4]  
Drucker J, 1986, Dev Biol Stand, V65, P145
[5]   COMBINATION VACCINES - HOPES AND CHALLENGES [J].
EDWARDS, KM ;
DECKER, MD .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1994, 13 (05) :345-347
[6]  
EDWARDS KM, 1993, J INFECT DIS, V168, P15, DOI 10.1093/infdis/168.1.15
[7]   SIMULTANEOUS ADMINISTRATION OF CHILDHOOD VACCINES - AN IMPORTANT PUBLIC-HEALTH POLICY THAT IS SAFE AND EFFICACIOUS [J].
KING, GE ;
HADLER, SC .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1994, 13 (05) :394-407
[8]   ISOTYPE AND ANTIGEN-SPECIFICITY OF PERTUSSIS AGGLUTININS FOLLOWING WHOLE-CELL PERTUSSIS VACCINATION AND INFECTION WITH BORDETELLA-PERTUSSIS [J].
MINK, CM ;
OBRIEN, CH ;
WASSILAK, S ;
DEFOREST, A ;
MEADE, BD .
INFECTION AND IMMUNITY, 1994, 62 (03) :1118-1120
[9]  
Qureshi A W, 1989, J Pak Med Assoc, V39, P31
[10]   DTP AND DTP-INACTIVATED POLIO VACCINES - COMPARISON OF ADVERSE REACTIONS AND IGG, IGM AND IGA ANTIBODY-RESPONSES TO DTP [J].
RUUSKANEN, O ;
VILJANEN, MK ;
SALMI, TT ;
LEHTONEN, OP ;
KOUVALAINEN, K ;
PELTONEN, T .
ACTA PAEDIATRICA SCANDINAVICA, 1980, 69 (02) :177-182