Arabidopsis mutants sensitive to gamma radiation include the homologue of the human repair gene ERCC1

被引：69

作者：

Hefner, E ^{[1
]}

Preuss, SB ^{[1
]}

Britt, AB ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Plant Biol, Genet Grad Grp, Davis, CA 95616 USA

来源：

JOURNAL OF EXPERIMENTAL BOTANY | 2003年 / 54卷 / 383期

基金：

美国国家科学基金会;

关键词：

Arabidopsis; DNA repair; double-strand breaks; ERCC1; ionizing radiation sensitive; Rad10; UV;

D O I：

10.1093/jxb/erg069

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Mutants sensitive to ionizing radiation in yeast and mammals include an assortment of DNA repair genes. The majority of these DNA repair genes are involved in the repair of DNA double-strand breaks. In this study a forward genetic screen is used to identify gamma-sensitive mutants of Arabidopsis thaliana. The gamma-plantlet screen used here also reveals two general mutant classes based on size of cotyledons and hypocotyls. One of the mutants discovered is a homologue of the mammalian nucleotide excision repair gene ERCC1.

引用

页码：669 / 680

页数：12

共 44 条

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