Structure-based design of non-peptidic pyridone aldehydes as inhibitors of interleukin-1 beta converting enzyme.

被引：26

作者：

Golec, JMC

Mullican, MD

Murcko, MA

Wilson, KP

Kay, DP

Jones, SD

Murdoch, R

Bemis, GW

Raybuck, SA

Luong, YP

Livingston, DJ

机构：

[1] VERTEX PHARMACEUT INC,CAMBRIDGE,MA 02139

[2] ROUSSEL LABS LTD,SWINDON SN3 5BZ,WILTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(97)00394-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：2181 / 2186

页数：6

共 28 条

[1] Human ICE/CED-3 protease nomenclature [J].

Alnemri, ES ;

Livingston, DJ ;

Nicholson, DW ;

Salvesen, G ;

Thornberry, NA ;

Wong, WW ;

Yuan, JY .

CELL, 1996, 87 (02) :171-171

[2]

ATOR MA, 1995, CURR PHARM DESIGN, V1, P191

[3] ACTIVATION OF INTERLEUKIN-1-BETA BY A CO-INDUCED PROTEASE [J].

BLACK, RA ;

KRONHEIM, SR ;

SLEATH, PR .

FEBS LETTERS, 1989, 247 (02) :386-390

[4] DESIGN OF ORALLY-ACTIVE, NONPEPTIDIC INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE [J].

BROWN, FJ ;

ANDISIK, DW ;

BERNSTEIN, PR ;

BRYANT, CB ;

CECCARELLI, C ;

DAMEWOOD, JR ;

WOOLSON, SA ;

EDWARDS, PD ;

EARLEY, RA ;

FEENEY, S ;

GREEN, RC ;

GOMES, B ;

KOSMIDER, BJ ;

KRELL, RD ;

SHAW, A ;

STEELMAN, GB ;

THOMAS, RN ;

VACEK, EP ;

VEALE, CA ;

TUTHILL, PA ;

WARNER, P ;

WILLIAMS, JC ;

WOLANIN, DJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (09) :1259-1261

[5] INTERFERON-GAMMA RECEPTOR-DEFICIENT MICE ARE RESISTANT TO ENDOTOXIC-SHOCK [J].

CAR, BD ;

ENG, VM ;

SCHNYDER, B ;

OZMEN, L ;

HUANG, S ;

GALLAY, P ;

HEUMANN, D ;

AGUET, M ;

RYFFEL, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (05) :1437-1444

[6] SYNTHESIS OF A POTENT, REVERSIBLE INHIBITOR OF INTERLEUKIN-1-BETA CONVERTING ENZYME [J].

CHAPMAN, KT .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (06) :613-618

[7] MULTIPLE DEFECTS OF IMMUNE CELL-FUNCTION IN MICE WITH DISRUPTED INTERFERON-GAMMA GENES [J].

DALTON, DK ;

PITTSMEEK, S ;

KESHAV, S ;

FIGARI, IS ;

BRADLEY, A ;

STEWART, TA .

SCIENCE, 1993, 259 (5102) :1739-1742

[8] NONPEPTIDIC INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .2. DESIGN, SYNTHESIS, AND IN-VITRO ACTIVITY OF A SERIES OF 3-AMINO-6-ARYLOPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES [J].

DAMEWOOD, JR ;

EDWARDS, PD ;

FEENEY, S ;

GOMES, BC ;

STEELMAN, GB ;

TUTHILL, PA ;

WILIIAMS, JC ;

WARNER, P ;

WOOLSON, SA ;

WOLANIN, DJ ;

VEALE, CA .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (20) :3303-3312

[9]

DINARELLO CA, 1994, EUR CYTOKINE NETW, V5, P517

[10] Pyridazinodiazepines as a high-affinity, P-2-P-3 peptidomimetic class of interleukin-1 beta-converting enzyme inhibitor [J].

Dolle, RE ;

Prasad, CVC ;

Prouty, CP ;

Salvino, JM ;

Awad, MMA ;

Schmidt, SJ ;

Hoyer, D ;

Ross, TM ;

Graybill, TL ;

Speier, GJ ;

Uhl, J ;

Miller, BE ;

Helaszek, CT ;

Ator, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (13) :1941-1946

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