(micro)genomic medicine microRNAs as therapeutics and biomarkers

被引：25

作者：

Saunders, Matthew A. ^{[1
]}

Lim, Lee P. ^{[1
]}

机构：

[1] Sirna Therapeut, San Francisco, CA 94158 USA

来源：

RNA BIOLOGY | 2009年 / 6卷 / 03期

关键词：

microRNAs; therapeutics; biomarkers; genomics; antagonists; agonists; MUSCLE-SPECIFIC MICRORNA; HEPATITIS-C VIRUS; TUMOR-SUPPRESSOR; MESSENGER-RNAS; CELL-CYCLE; IN-VIVO; GENE-EXPRESSION; TARGET; CANCER; IDENTIFICATION;

D O I：

10.4161/rna.6.3.8871

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomic studies have shown that a microRNA(miRNA) can post-transcriptionally regulate hundreds of other genes, providing challenges and opportunities for therapeutic development. Profiling studies have placed several miRNAs within transcriptional pathways linked to disease, and oligonucleotide therapeutics are being developed that modulate miRNA activity. The involvement of miRNAs in diverse genetic pathways across human tissues suggests that miRNAs will also be useful as biomarkers for disease and tissue injury.

引用

页码：324 / 328

页数：5

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