Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)

被引：129

作者：

Biver, Emmanuel ^{[1
,2
]}

Berenbaum, Francis ^{[3
]}

Valdes, Ana M. ^{[4
]}

de Carvalho, Islene Araujo ^{[5
]}

Bindels, Laure B. ^{[6
]}

Brand, Maria Luisa ^{[7
]}

Calder, Philip C. ^{[8
,9
,10
]}

Castronovo, Vincenzo ^{[11
]}

Cavalier, Etienne ^{[12
]}

Cherubini, Antonio ^{[13
,14
]}

Cooper, Cyrus ^{[15
,16
]}

Dennison, Elaine ^{[15
]}

Franceschi, Claudio ^{[17
]}

Fuggle, Nicholas ^{[15
]}

Laslop, Andrea ^{[18
]}

Miossec, Pierre ^{[19
,20
]}

Thomas, Thierry ^{[21
,22
]}

Tuzun, Sansin ^{[23
]}

Veronese, Nicola ^{[24
]}

Vlaskovska, Mila ^{[25
]}

Reginster, Jean-Yves ^{[26
,27
]}

Rizzoli, Rene ^{[1
,2
]}

机构：

[1] Univ Geneva, Geneva Univ Hosp, Div Bone Dis, 4 Rue Gabrielle Perret Gentil, CH-1205 Geneva, Switzerland

[2] Univ Geneva, Fac Med, 4 Rue Gabrielle Perret Gentil, CH-1205 Geneva, Switzerland

[3] Sorbonne Univ, St Antoine Hosp, AP HP, Dept Rheumatol,INSERM CRSA, Paris, France

[4] Univ Nottingham, Sch Med, Div Rheumatol Orthopaed & Dermatol, Nottingham, England

[5] World Hlth Org, Dept Ageing & Life Course, 20 Ave Appia, CH-1211 Geneva 27, Switzerland

[6] Catholic Univ Louvain, Metab & Nutr Res Grp, Louvain Drug Res Inst, Brussels, Belgium

[7] Univ Florence, Dept Biomed Expt & Clin Sci, Bone Metab Dis Unit, Florence, Italy

[8] Univ Southampton, Fac Med, Human Dev & Hlth, Southampton, Hants, England

[9] Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England

[10] Univ Southampton, Southampton, Hants, England

[11] Univ Liege, GIGA Canc, Metastases Res Lab, Liege, Belgium

[12] Univ Liege, CHU Liege, Dept Clin Chem, Liege, Belgium

[13] IRCCS INRCA, Geriatria Accettaz Geriatr, Ancona, Italy

[14] IRCCS INRCA, Ctr Ric Invecchiamento, Ancona, Italy

[15] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England

[16] Univ Oxford, NIHR Oxford Biomed Res Ctr, Oxford, England

[17] Univ Bologna, Dept Specialty Diagnost & Expt Med DIMES, Bologna, Italy

[18] Fed Off Safety Hlth Care, Austrian Med & Med Devices Agcy, Sci Off, Vienna, Austria

[19] Univ Lyon, Immunogen & Inflammat Res Unit, EA 4130, Lyon, France

[20] Hosp Civils Lyon, Dept Clin Immunol & Rheumatol, Lyon, France

[21] Hop Nord St Etienne, CHU St Etienne, Dept Rheumatol, St Etienne, France

[22] Univ Lyon, INSERM U1059, St Etienne, France

[23] Istanbul Univ Cerralipmsa, Cerrahpasa Med Fac, Dept Phys Med & Rehabil, Istanbul, Turkey

[24] CNR, Neurosci Inst, Aging Branch, Padua, Italy

[25] Med Univ Sofia, Dept Pharmacol, Med Fac, Sofia, Bulgaria

[26] Univ Liege, Dept Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium

[27] King Saud Univ, Biochem Dept, Coll Sci, Chair Biomarkers Chron Dis, Riyadh, Saudi Arabia

来源：

AGEING RESEARCH REVIEWS | 2019年 / 55卷

关键词：

Osteoarthritis; Gut microbiota; Dysbiosis; Inflammaging; Obesity; Modern diet; BODY-MASS INDEX; LOW-GRADE INFLAMMATION; KNEE OSTEOARTHRITIS; CHONDROITIN SULFATE; METABOLIC OSTEOARTHRITIS; HAND OSTEOARTHRITIS; OBESE-PATIENTS; DIETARY FIBER; CARTILAGE; ASSOCIATION;

D O I：

10.1016/j.arr.2019.100946

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The prevalence of osteoarthritis (OA) increases not only because of longer life expectancy but also because of the modern lifestyle, in particular physical inactivity and diets low in fiber and rich in sugar and saturated fats, which promote chronic low-grade inflammation and obesity. Adverse alterations of the gut microbiota (GMB) composition, called microbial dysbiosis, may favor metabolic syndrome and inflammaging, two important components of OA onset and evolution. Considering the burden of OA and the need to define preventive and therapeutic interventions targeting the modifiable components of OA, an expert working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) to review the potential contribution of GMB to OA. Such a contribution is supported by observational or dietary intervention studies in animal models of OA and in humans. In addition, several well-recognized risk factors of OA interact with GMB. Lastly, GMB is a critical determinant of drug metabolism and bioavailability and may influence the response to OA medications. Further research targeting GMB or its metabolites is needed to move the field of OA from symptomatic management to individualized interventions targeting its pathogenesis.

引用

页数：8

共 87 条

[21]

Response to diet-induced obesity produces time-dependent induction and progression of metabolic osteoarthritis in rat knees [J].