The Flow's the Thing ... Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow

被引：154

作者：

Valera, Fernando E. ^{[2
]}

Quaranta, Michela ^{[3
]}

Moran, Antonio ^{[3
]}

Blacker, John ^{[1
]}

Armstrong, Alan ^{[3
]}

Cabral, Joao T. ^{[2
]}

Blackmond, Donna G. ^{[2
]}

机构：

[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Chem Engn & Chem Technol, London SW7 2AZ, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 14期

基金：

英国工程与自然科学研究理事会;

关键词：

kinetics; microreactors; organocatalysis; reaction mechanisms; PROGRESS KINETIC-ANALYSIS; REACTORS; SYSTEM; MICROREACTORS; ALDOL;

D O I：

10.1002/anie.200906095

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Figure presented" Against the flow? What factors dictate the relative merits of microflow reactors versus batch-reaction flasks for homogeneous catalytic reactions? The optimal reaction protocol must be decided on a case-by-case basis. Flask reactors equipped with in situ detection devices provide a concise and information-rich means of obtaining the intrinsic kinetic information required to make this decision. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA."

引用

页码：2478 / 2485

页数：8

共 33 条

[1]

[Anonymous], 2005, ANGEW CHEM-GER EDIT

[2]

[Anonymous], 1999, PROCESS CHEM PHARM I

[3]

Baxendale I. R., 2009, ANGEW CHEM, V121, P4077

[4] Microwave reactions under continuous flow conditions [J].

Baxendale, Ian R. ;

Hayward, John J. ;

Ley, Steven V. .

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2007, 10 (10) :802-836

[5] Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles [J].

Baxendale, Ian R. ;

Ley, Steven V. ;

Mansfield, Andrew C. ;

Smith, Christopher D. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (22) :4017-4021

[6]

BAXENDALE IR, 2008, MICROREACTORS ORGANI, P84

[7] Kinetic aspects of nonlinear effects in asymmetric catalysis [J].

Blackmond, DG .

ACCOUNTS OF CHEMICAL RESEARCH, 2000, 33 (06) :402-411

[8] Reaction progress kinetic analysis: A powerful methodology for mechanistic studies of complex catalytic reactions [J].

Blackmond, DG .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (28) :4302-4320

[9]

Bogdan A. R., 2009, ANGEW CHEM, V121, P8699

[10] The Continuous-Flow Synthesis of Ibuprofen [J].

Bogdan, Andrew R. ;

Poe, Sarah L. ;

Kubis, Daniel C. ;

Broadwater, Steven J. ;

McQuade, D. Tyler .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (45) :8547-8550

← 1 2 3 4 →