Multi-atmospheric pressure ionisation interface for liquid chromatography mass spectrometry

被引：16

作者：

Sakairi, M ^{[1
]}

Kato, Y

机构：

[1] Hitachi Ltd, Cent Res Lab, Kokubunji, Tokyo 185, Japan

[2] Hitachi Ltd, Instrument Div, Hitachi, Ibaragi 312, Japan

来源：

JOURNAL OF CHROMATOGRAPHY A | 1998年 / 794卷 / 1-2期

关键词：

interfaces; LC-MS; multi-atmospheric pressure ionisation interface; mass spectrometry;

D O I：

10.1016/S0021-9673(97)01220-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We describe the structure of a multi-atmospheric pressure ionisation (multi-API) interface for liquid chromatography-mass spectrometry (LC-MS). This interface includes five modes of atmospheric pressure spray with electron impact ionisation (APEI), atmospheric pressure chemical ionisation (APCI), atmospheric pressure spray ionisation (APSI), electrospray ionisation (ESI) and sonic spray ionisation (SSI). This LC-MS system was realised by developing an APEI interface which resembles other API interfaces and a highly sensitive API interface using advanced collision induced dissociation in a differential pumping region and an electrostatic ion guide. This system can deal with a wide variety of organic compounds from hydrocarbons with low polarity to proteins with high polarity by using the five modes. (C) 1998 Published by Elsevier Science B.V.

引用

页码：391 / 406

页数：16

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