共 38 条
Detrusor contraction - Focus on muscarinic receptors
被引:13
作者:
Andersson, KE
[1
]
机构:
[1] Univ Lund Hosp, Dept Clin & Expt Pharmacol, SE-22185 Lund, Sweden
来源:
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY
|
2004年
/
38卷
关键词:
bladder;
signal transduction;
contractile proteins;
calcium sensitivity;
acetylcholine;
D O I:
10.1080/03008880410015192
中图分类号:
R5 [内科学];
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号:
1002 ;
100201 ;
摘要:
Stimulation of muscarinic receptors is a main mechanism for contractile activation of the detrusor from both animals and humans. Muscarinic receptors are coupled to G-proteins, but the signal transduction systems may vary. In general, M-1 , M-3 and M-5 receptors are considered to couple preferentially to G(q/11) , activating phosphoinositide hydrolysis, in turn leading to mobilization of intracellular calcium through inositol trisphosphate generation. M-2 and M-4 receptors couple to pertussis toxin-sensitive G(i/o) , resulting in inhibition of adenylyl cyclase activity. However, in the detrusor smooth muscle, other signalling pathways may be involved. Recent investigations revealed that a main pathway for muscarinic receptor activation of the detrusor may be calcium influx via L-type calcium channels, and increased sensitivity to calcium of the contractile machinery via inhibition of myosin light chain phosphatase through activation of Rho-kinase. The importance of these findings for treatment of voiding dysfunction remains to be established.
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页码:54 / 57
页数:4
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