Detrusor contraction - Focus on muscarinic receptors

被引:13
作者
Andersson, KE [1 ]
机构
[1] Univ Lund Hosp, Dept Clin & Expt Pharmacol, SE-22185 Lund, Sweden
来源
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY | 2004年 / 38卷
关键词
bladder; signal transduction; contractile proteins; calcium sensitivity; acetylcholine;
D O I
10.1080/03008880410015192
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Stimulation of muscarinic receptors is a main mechanism for contractile activation of the detrusor from both animals and humans. Muscarinic receptors are coupled to G-proteins, but the signal transduction systems may vary. In general, M-1 , M-3 and M-5 receptors are considered to couple preferentially to G(q/11) , activating phosphoinositide hydrolysis, in turn leading to mobilization of intracellular calcium through inositol trisphosphate generation. M-2 and M-4 receptors couple to pertussis toxin-sensitive G(i/o) , resulting in inhibition of adenylyl cyclase activity. However, in the detrusor smooth muscle, other signalling pathways may be involved. Recent investigations revealed that a main pathway for muscarinic receptor activation of the detrusor may be calcium influx via L-type calcium channels, and increased sensitivity to calcium of the contractile machinery via inhibition of myosin light chain phosphatase through activation of Rho-kinase. The importance of these findings for treatment of voiding dysfunction remains to be established.
引用
收藏
页码:54 / 57
页数:4
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