Human genetics - Hair apparent

被引:5
作者
Davies, K [1 ]
机构
[1] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA
关键词
D O I
10.1038/35264
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Treatments for baldness usually involve rubbing lotions onto the surface of the scalp. But one group is now making headway towards a more scientific cure by homing in on the root cause -- one of the genes that is responsible for baldness. By studying seven members of a Pakistani family with a recessively inherited form of baldness known as alopecia universalis, the authors identified a region on the short arm of chromosome 8 that is often mutated. They narrowed this down even further by cloning the human homologue of the mousehairlessgene, which turned out to map to this exact region. This is the first documented genetic mutation to be associated exclusively with hair loss.
引用
收藏
页码:537 / +
页数:2
相关论文
共 12 条
[1]   Alopecia universalis associated with a mutation in the human hairless gene [J].
Ahmad, W ;
Haque, WFU ;
Brancolini, V ;
Tsou, HC ;
Haque, SU ;
Lam, H ;
Aita, VM ;
Owen, J ;
deBlaquiere, M ;
Frank, J ;
Cserhalmi-Friedman, PB ;
Leask, A ;
McGrath, JA ;
Peacocke, M ;
Ahmad, M ;
Ott, J ;
Christiano, AM .
SCIENCE, 1998, 279 (5351) :720-724
[2]   STRUCTURE AND EXPRESSION OF THE HAIRLESS GENE OF MICE [J].
CACHONGONZALEZ, MB ;
FENNER, S ;
COFFIN, JM ;
MORAN, C ;
STOYE, JP ;
BEST, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) :7717-7721
[3]   Growth factors and cytokines in hair follicle development and cycling: Recent insights from animal models and the potentials for clinical therapy [J].
Danilenko, DM ;
Ring, BD ;
Pierce, GF .
MOLECULAR MEDICINE TODAY, 1996, 2 (11) :460-467
[4]   MAPPING OF THE CONGENITAL GENERALIZED HYPERTRICHOSIS LOCUS TO CHROMOSOME XQ24-Q27.1 [J].
FIGUERA, LE ;
PANDOLFO, M ;
DUNNE, PW ;
CANTU, JM ;
PATEL, PI .
NATURE GENETICS, 1995, 10 (02) :202-207
[5]   THE SECRET LIFE OF THE HAIR FOLLICLE [J].
HARDY, MH .
TRENDS IN GENETICS, 1992, 8 (02) :55-61
[6]   X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein [J].
Kere, J ;
Srivastava, AK ;
Montonen, O ;
Zonana, J ;
Thomas, N ;
Ferguson, B ;
Munoz, F ;
Morgan, D ;
Clarke, A ;
Baybayan, P ;
Chen, EY ;
Ezer, S ;
SaarialhoKere, U ;
delaChapelle, A ;
Schlessinger, D .
NATURE GENETICS, 1996, 13 (04) :409-416
[7]  
KORNHEISER T, 1997, BALD I WANNA BE
[8]   THE FEASIBILITY OF TARGETED SELECTIVE GENE-THERAPY OF THE HAIR FOLLICLE [J].
LI, LN ;
HOFFMAN, RM .
NATURE MEDICINE, 1995, 1 (07) :705-706
[9]   NEW MEMBER OF THE WINGED-HELIX PROTEIN FAMILY DISRUPTED IN MOUSE AND RAT NUDE MUTATIONS [J].
NEHLS, M ;
PFEIFER, D ;
SCHORPP, M ;
HEDRICH, H ;
BOEHM, T .
NATURE, 1994, 372 (6501) :103-107
[10]  
NOTHEN MM, IN PRESS AM J HUM GE