The disposition index: adjustment for peripheral vs. hepatic insulin sensitivity?

被引：39

作者：

Faerch, K. ^{[1
]}

Brons, C. ^{[1
]}

Alibegovic, A. C. ^{[1
]}

Vaag, A. ^{[1
]}

机构：

[1] Steno Diabet Ctr, DK-2820 Gentofte, Denmark

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2010年 / 588卷 / 05期

关键词：

IMPAIRED GLUCOSE-TOLERANCE; BETA-CELL FUNCTION; FASTING GLUCOSE; SKELETAL-MUSCLE; RESISTANCE; HUMANS; ALLOSTASIS; SECRETION; LIVER; CLAMP;

D O I：

10.1113/jphysiol.2009.184028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The assessment of pancreatic beta cell function in humans is challenging because of a complex interplay between insulin secretion, insulin sensitivity and hepatic insulin extraction. Simplified, the relationship between insulin secretion and insulin sensitivity can be described by an approximate hyperbola with the product of the two variables being constant for individuals with the same degree of glucose tolerance (the disposition index). Strengths and limitations of the disposition index have been widely debated in the literature. In this review we will focus on another and until recently unrecognized dimension of the disposition index, namely the issue of adjusting insulin secretion for hepatic versus peripheral insulin sensitivity. An underlying assumption of this issue is that the liver as compared to muscle plays a different role in the regulation of in vivo insulin secretion.

引用

收藏

页码：759 / 764

页数：6

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