Bidirectional synaptic plasticity: from theory to reality

被引：195

作者：

Bear, MF ^{[1
]}

机构：

[1] Brown Univ, Howard Hughes Med Inst, Dept Neurosci, Providence, RI 02912 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES | 2003年 / 358卷 / 1432期

关键词：

long-term depression; metaplasticity; visual cortex; ocular dominance plasticity; Hebb; Bienenstock-Cooper-Munro (BCM) theory;

D O I：

10.1098/rstb.2002.1255

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Theories of receptive field plasticity and information storage make specific assumptions for how synapses are modified. I give a personal account of how testing the validity of these assumptions eventually led to a detailed understanding of long-term depression and metaplasticity in hippocampal area CA1 and the visual cortex. The knowledge of these molecular mechanisms now promises to reveal when and how sensory experience modifies synapses in the cerebral cortex.

引用

页码：649 / 655

页数：7

共 49 条

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