RNA as a target for small-molecule therapeutics

被引:46
作者
Hermann, T
Tor, Y
机构
[1] Anadys Pharmaceut Inc, Dept Struct Chem, San Diego, CA 92121 USA
[2] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
关键词
aminoglycosides; HIV; ribosome; RNase P; X-ray crystallography;
D O I
10.1517/13543776.15.1.49
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Natural antibiotics that specifically target RNA components of the bacterial ribosome set precedence for RNA-directed small-molecule drugs. Structured domains of functional RNAs in bacteria and viruses have thus attracted attention as targets for the discovery of novel anti-infectives. Whereas a growing number of RNA-directed ligands have been reported in the literature, creating synthetic molecules that combine high affinity with selectivity for a specific RNA target remains a key challenge. Ongoing discovery efforts towards this goal, combined with the increasing knowledge of the factors that govern small-molecule recognition of RNA folds, will prepare the ground for the development of novel RNA-targeted therapeutics.
引用
收藏
页码:49 / 62
页数:14
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