Unconventional motoring: An overview of the Kin C and Kin I kinesins

被引：33

作者：

Ovechkina, Y ^{[1
]}

Wordeman, L ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA

来源：

TRAFFIC | 2003年 / 4卷 / 06期

关键词：

depolymerization; Kar3; KIF2; kinesin; Kip3; KIp5/6; MCAK; microtubule dynamics; motor; XKCM1;

D O I：

10.1034/j.1600-0854.2003.00099.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

All kinesins share a conserved core motor domain implying a common mechanism for generating force from ATP hydrolysis. How is it then that kinesins exhibit such divergent activities: motility, microtubule cross-linking and microtubule depolymerization? Although conventional motile kinesins have served as the paradigm for understanding kinesin function, the unconventional kinesins exploit variations on the motile theme to perform unexpected tasks. This review summarizes the biological functions and examines the possible molecular mechanisms of Kin C and Kin I unconventional kinesins. We also discuss the possible differences between the microtubule destabilization models proposed for Kar3 and Kin I kinesins.

引用

页码：367 / 375

页数：9

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