Spin-state rationale for the peroxo-stabilizing role of the thiolate ligand in superoxide reductase

被引：46

作者：

Bukowski, MR

Halfen, HL

van den Berg, TA

Halfen, JA

Que, L

机构：

[1] Univ Minnesota, Ctr Met & Biocatalysis, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

[3] Univ Wisconsin, Dept Chem, Eau Claire, WI 54702 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 04期

关键词：

bioinorganic chemistry; coordination compounds; iron; peroxides; S ligands;

D O I：

10.1002/anie.200461527

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Anti-push: The axial thiolate ligand stabilizes high-spin Fe III-OOR species (see picture) such as those found in superoxide reductase. This situation is in contrast to the "push effect" observed in structurally similar low-spin FeIII-OOR systems, including cytochrome P450, which promote O-O bond cleavage. These results show how very similar enzyme-active sites can carry out two very different functions.

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页码：584 / 587

页数：4

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