High levels of hyaluronan production by a malignant lymphoma cell line with primary effusion lymphoma immunophenotype OHK

被引：7

作者：

Kuwabara, H

Yoneda, M

Nagai, M

Nishio, H

Tasaka, T

Suzuki, K

Mori, H

机构：

[1] Osaka Med Coll, Dept Pathol, Osaka, Japan

[2] Aichi Prefectural Coll Nursing & Hlth, Biochem & Mol Biol Lab, Aichi, Japan

[3] Kagawa Med Univ, Dept Internal Med, Kagawa, Japan

[4] Osaka Med Coll, Dept Legal Med, Osaka, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 120卷 / 06期

关键词：

hyaluronan; PEL; OHK; synthase;

D O I：

10.1046/j.1365-2141.2003.04206.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated whether hyaluronan (HA) was produced by a malignant lymphoma cell line with a primary effusion lymphoma immunophenotype, OHK. OHK secreted high levels of HA into the culture supernatant, and reverse transcription polymerase chain reaction showed mRNA for the HA synthases 2 and 3. HA binding protein-reactive HA was present in the plasma membrane and in the cytoplasm. The inoculation of OHK into severe combined immunodeficiency disease mice produced marked viscid ascites with concentrated HA and a vascular-rich mesenteric solid tumour. These results show that HA is produced and secreted by the malignant lymphoma cell line OHK.

引用

页码：1055 / 1057

页数：3

共 13 条

[11] The KSHV/HHV8-infected BCBL-1 lymphoma line causes tumors in SCID mice but fails to transmit virus to a human peripheral blood mononuclear cell graft [J].