Palladium-catalyzed amination of aryl bromides with hindered N-alkyl-substituted anilines using a pallidium(I) tri-tert-butylphosphine bromide dimer

被引：72

作者：

Prashad, M ^{[1
]}

Mak, XY ^{[1
]}

Liu, YG ^{[1
]}

Repic, O ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, E Hanover, NJ 07936 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 03期

关键词：

D O I：

10.1021/jo020609d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient palladium-catalyzed amination of aromatic bromides with hindered N-alkyl-substituted anilines is described, either using the combination of Pd(OAc)(2) and P(t-BU)(3) or a palladium(l) tri-tert-butylphosphine bromide dimer, [Pd(mu-Br)(t-BU3P)](2), a new, commercially available, and easily handled catalyst.

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收藏

页码：1163 / 1164

页数：2

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