miR-24 up-regulation in oral carcinoma: Positive association from clinical and in vitro analysis

被引：136

作者：

Lin, Shu-Chun ^{[1
]}

Liu, Chung-Ji ^{[1
,2
]}

Lin, Jung-An ^{[1
]}

Chiang, Wei-Fan ^{[1
,3
]}

Hung, Pei-Shih ^{[1
]}

Chang, Kuo-Wei ^{[1
,4
]}

机构：

[1] Natl Yang Ming Univ, Sch Dent, Taipei 112, Taiwan

[2] MacKay Mem Hosp, Taipei, Taiwan

[3] Chimei Hosp, Dept Dent, Tainan, Taiwan

[4] Vet Gen Hosp, Dept Stomatol, Taipei, Taiwan

来源：

ORAL ONCOLOGY | 2010年 / 46卷 / 03期

关键词：

Carcinoma; MicroRNA; Oral cavity; Plasma; Proliferation; miR-24; SQUAMOUS-CELL CARCINOMA; MICRORNA; CANCER; EXPRESSION; TONGUE; HEAD;

D O I：

10.1016/j.oraloncology.2009.12.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) play important roles in neoplastic process. miR-24 is localized on chromosome 9q22 and 19p13, regions frequently altered in oral squamous cell carcinoma (OSCC). This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSCC patients were significantly higher than in control individuals. miR-24 expression was also higher in OSCC cell lines relative to normal oral keratinocytes. Experiments blocking miR-24 and using exogenous miR-24 expression indicated that miR-24 contributes to the growth of OSCC cells and that miR-24 may target p57. This study suggests that miR-24 is involved in the regulation of OSCC growth and that the miR-24's level in plasma may be validatable as a tumor marker for OSCC patients. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：204 / 208

页数：5

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