OMEGA-3 FATTY ACIDS AND BLOOD PRESSURE

被引:29
作者
Mori, T. A. [1 ,2 ]
机构
[1] Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp Unit, Perth, WA 6009, Australia
[2] Cardiovasc Res Ctr, Perth, WA, Australia
关键词
Omega-3 fatty acids; blood pressure; hypertension; vascular function; N-3; FATTY-ACIDS; PURIFIED EICOSAPENTAENOIC ACID; CORONARY-HEART-DISEASE; FISH-OIL SUPPLEMENTATION; ENDOTHELIUM-DEPENDENT RESPONSES; FOREARM RESISTANCE VESSELS; SUDDEN CARDIAC DEATH; COD-LIVER OIL; DOCOSAHEXAENOIC ACID; DIETARY SUPPLEMENTATION;
D O I
10.1170/T881
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
There is substantial evidence that omega 3 fatty acids reduce blood pressure, with a greater effect in hypertensive patients and those with high-normal blood pressure. The dose of omega 3 fatty acids required to achieve a blood pressure reduction is likely to be at least 3-4 g/day. However, the magnitude of the blood pressure change can be increased by salt restriction or when omega 3 fatty acids are incorporated into a weight reducing program. It is also highly plausible that increased omega 3 fatty acid consumption as part of a dietary change including increased consumption of fruits and vegetables, and moderation of salt intake, will confer significant cardiovascular benefit.
引用
收藏
页码:83 / 92
页数:10
相关论文
共 103 条
[71]  
NISHIMURA M, 2007, CLIN EXPT PHARM PHYS, V27, P618
[72]   EFFECT OF DIETARY SUPPLEMENTATION WITH FISH OIL ON SYSTOLIC BLOOD-PRESSURE IN MILD ESSENTIAL-HYPERTENSION [J].
NORRIS, PG ;
JONES, CJH ;
WESTON, MJ .
BRITISH MEDICAL JOURNAL, 1986, 293 (6539) :104-105
[73]  
Panagiotakos DB, 2007, MED SCI MONITOR, V13, pCR307
[74]   Blood pressure and atherogenic lipoprotein profiles of fish-diet and vegetarian villagers in Tanzania: The Lugalawa study [J].
Pauletto, P ;
Puato, M ;
Caroli, MG ;
Casiglia, E ;
Munhambo, AE ;
Cazzolato, G ;
Bon, GB ;
Angeli, MT ;
Galli, C ;
Pessina, AC .
LANCET, 1996, 348 (9030) :784-788
[75]   FLOW-MEDIATED VASODILATION AND DIETARY INTAKE OF N-3 POLYUNSATURATED ACIDS IN HEALTHY SUBJECTS [J].
Petersen, M. M. ;
Eschen, R. B. ;
Aardestrup, I. ;
Obel, T. ;
Schmidt, E. B. .
CELLULAR AND MOLECULAR BIOLOGY, 2010, 56 (01) :38-44
[76]   Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients [J].
Prisco, D ;
Paniccia, R ;
Bandinelli, B ;
Filippini, M ;
Francalanci, I ;
Giusti, B ;
Giurlani, L ;
Gensini, GF ;
Abbate, R ;
Serneri, GGN .
THROMBOSIS RESEARCH, 1998, 91 (03) :105-112
[77]   THE EFFECTS OF LOW-DOSES OF N-3 FATTY-ACID SUPPLEMENTATION ON BLOOD-PRESSURE IN HYPERTENSIVE SUBJECTS - A RANDOMIZED CONTROLLED TRIAL [J].
RADACK, K ;
DECK, C ;
HUSTER, G .
ARCHIVES OF INTERNAL MEDICINE, 1991, 151 (06) :1173-1180
[78]   Eicosapentaenoic acid is primarily responsible for hypotriglyceridemic effect of fish oil in humans [J].
Rambjor, GS ;
Walen, AI ;
Windsor, SL ;
Harris, WS .
LIPIDS, 1996, 31 :S45-S49
[79]   Effects on blood pressure of reduced dietary sodium and the dietary approaches to stop hypertension (DASH) diet. [J].
Sacks, FM ;
Svetkey, LP ;
Vollmer, WM ;
Appel, LJ ;
Bray, GA ;
Harsha, D ;
Obarzanek, E ;
Conlin, PR ;
Miller, ER ;
Simons-Morton, DG ;
Karanja, N ;
Lin, PH .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (01) :3-10
[80]   EICOSAPENTAENOIC ACID POTENTIATES THE PRODUCTION OF NITRIC-OXIDE EVOKED BY INTERLEUKIN-1-BETA IN CULTURED VASCULAR SMOOTH-MUSCLE CELLS [J].
SCHINI, VB ;
DURANTE, W ;
CATOVSKY, S ;
VANHOUTTE, PM .
JOURNAL OF VASCULAR RESEARCH, 1993, 30 (04) :209-217