Direct Ruthenium-Catalyzed C-C Coupling of Ethanol: Diene Hydro-hydroxyethylation To Form All-Carbon Quaternary Centers

被引：39

作者：

Han, Hoon ^{[1
]}

Krische, Michael J. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 12期

关键词：

ALDEHYDE OXIDATION LEVEL; TRANSFER HYDROGENATION; BOND FORMATION; BETA; GAMMA-UNSATURATED KETONES; UNACTIVATED OLEFINS; COMPLEX CATALYST; 1,3-DIENES; ALCOHOL; HOMOALLYLATION; ALLYLATION;

D O I：

10.1021/ol101077v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under ruthenium-catalyzed transfer hydrogenation conditions, direct C C coupling of ethanol and 2-substituted dienes occurs to furnish products of hydro-hydroxyethylation: anti-configured neopentyl homoallylic alcohols. Identical adducts are generated from acetaldehyde under related conditions employing isopropanol as reductant.

引用

页码：2844 / 2846

页数：3

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