Nacre/bone interface changes in durable nacre endosseous implants in sheep

被引：59

作者：

Berland, S

Delattre, O

Borzeix, S

Catonné, Y

Lopez, E

机构：

[1] Museum Natl Hist Nat, Dept Milieux & Peuplements Aquat, CNRS, UMR 5178,USM 401, F-75231 Paris 05, France

[2] CHRU, Sce Chirurgie Orthoped & Traumatol, Ft DE France Martinique, France

来源：

BIOMATERIALS | 2005年 / 26卷 / 15期

关键词：

animal model; bone repair; nacre; histomorphometry; interface; bioerosion;

D O I：

10.1016/j.biomaterials.2004.07.019

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Raw nacre implants persist even after 9 months of implantation into bone tissue in sheep. However the nacre surface undergoes a limited biodegradation process. Smooth-surfaced nacre implants were seen to become microporous after implantation. The results of these long-term. in vivo studies show that the overall process involves bone-resorbing cells, relies on a two-phase mechanism and may correspond to a regulation process. The rate of surface change depends on the bone implantation site and the nacre/bone interaction. The in vivo biodegradability of nacre is a highly variable parameter. The size and shape of the implanted nacre and the cellular environment of the implant are key factors in determining the biodegradation kinetics of the nacre in a living system. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2767 / 2773

页数：7

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