Does neuropeptide Y (NPY) mediate the effects of psychotropic drugs?

被引：33

作者：

Obuchowicz, E ^{[1
]}

Krysiak, R ^{[1
]}

Herman, ZS ^{[1
]}

机构：

[1] Silesian Univ, Sch Med, Dept Clin Pharmacol, PL-40752 Katowice, Poland

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2004年 / 28卷 / 06期

关键词：

neuropeptide Y (NPY); anxiolytics; antidepressants; antipsychotic drugs; central nervous system; animal studies; clinical data;

D O I：

10.1016/j.neubiorev.2004.08.006

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Although several studies have summarized the effects of neuropeptide Y (NPY) in the central nervous system, its role in psychopharmacotherapy has not been reviewed in detail. For the last few years, there has been an increase in the number of studies on the suggested role of NPY in the benefits of treatment for mental disorders. Our review focuses on the possible involvement of altered NPY system activity in the effects of antianxiety, antidepressant and antipsychotic therapies. Potential sites and receptors, which are implicated in mediating the NPY effects of psychotropic drugs, have been described. We discuss the significance of alterations in the brain NPY system for the development of new methods of treatment for mental disorders. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：595 / 610

页数：16

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