Solid phase aldol and conjugate addition reactions using Evans' oxazolidinone chiral auxiliary

被引：85

作者：

Phoon, CW ^{[1
]}

Abell, C ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(98)00230-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Resin-supported Evans' chiral auxiliary is used in an aldol and a conjugate addition reaction on solid phase. The experiments show that solid-phase asymmetric reactions can reproduce the high enantiomeric excesses observed in solution phase reactions and also highlight specific problems associated with working on resin. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：2655 / 2658

页数：4

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