Cytotoxic resibufogenin transformation products from cell suspension cultures of Platycodon grandiflorum

被引：9

作者：

Li, LX ^{[1
]}

Li, P ^{[1
]}

Ye, M ^{[1
]}

Zhong, L ^{[1
]}

Guo, D ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

来源：

LETTERS IN ORGANIC CHEMISTRY | 2004年 / 1卷 / 02期

关键词：

Platycodon grandiflorum; campanulaceae; resibufogenin; biotransformation; cell suspension cultures;

D O I：

10.2174/1570178043488509

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four biotransformed products of resibufogenin were obtained after 4 days of incubation with cell suspension cultures of Platycodon grandiflorum. On the basis of chemical and spectral data, their structures were elucidated as 3-epi-resibufogenin. marinobufagin, 1beta-hydroxy-resibufogenin, and 3-epi-marinobufagin respectively, among which the latter two compounds are new. These compounds were found to exhibit potent cylotoxic activities against Bel-7402. BGC-823. HeLa, and HL-60 human cancer cell lines.

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页码：176 / 178

页数：3

相关论文

共 14 条

[1]

[Anonymous], ZHONG CAO YAO

[2] Regio- and stereo-selective biotransformation of 2α,5α,10β,14β-tetra-acetoxy-4(20), 11-taxadiene by Ginkgo cell suspension cultures [J].

Dai, JG ;

Ye, M ;

Guo, HZ ;

Zhu, WH ;

Zhang, DO ;

Hu, Q ;

Zheng, JH ;

Guo, D .

TETRAHEDRON, 2002, 58 (28) :5659-5668

[3] Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells [J].

Efferth, T ;

Davey, M ;

Olbrich, A ;

Rücker, G ;

Gebhart, E ;

Davey, R .

BLOOD CELLS MOLECULES AND DISEASES, 2002, 28 (02) :160-168

[4] Highly selective transformation by plant catalysts [J].

Hamada, H ;

Miyamoto, Y ;

Nakajima, N ;

Furuya, T .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 1998, 5 (1-4) :187-189

[5] Structure-cytotoxic activity relationship for the toad poison bufadienolides [J].

Kamano, Y ;

Kotake, A ;

Hashima, H ;

Inoue, M ;

Morita, H ;

Takeya, K ;

Itokawa, H ;

Nandachi, N ;

Segawa, T ;

Yukita, A ;

Saitou, K ;

Katsuyama, M ;

Pettit, GR .

BIOORGANIC & MEDICINAL CHEMISTRY, 1998, 6 (07) :1103-1115

[6] Bufadienolides from animal and plant sources [J].

Krenn, L ;

Kopp, B .

PHYTOCHEMISTRY, 1998, 48 (01) :1-29

[7] Biotransformation of triptonide by cell suspension cultures of Platycodon grandifiorum [J].

Ning, LL ;

Guo, HZ ;

Jiang, XM ;

Bi, KS ;

Guo, D .

PURE AND APPLIED CHEMISTRY, 2003, 75 (2-3) :389-392

[8] Biotransformation of triptolide by Cunninghamella blakesleana [J].

Ning, LL ;

Zhan, JX ;

Qu, GQ ;

Zhong, L ;

Guo, HZ ;

Bi, KS ;

Guo, D .

TETRAHEDRON, 2003, 59 (23) :4209-4213

[9] Biocatalytic dediastereomerization of dibenzylbutanolides by plant cell cultures [J].

Takemoto, M ;

Matsuoka, Y ;

Achiwa, K ;

Kutney, JP .

TETRAHEDRON LETTERS, 2000, 41 (04) :499-502

[10] Biotransformation of cinobufagin by cell suspension cultures of Catharanthus roseus and Platycodon grandiflorum [J].

Ye, M ;

Ning, LL ;

Zhan, JX ;

Guo, HZ ;

Guo, D .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2003, 22 (1-2) :89-95