Hard Luck Stories: The Reality of Endothelial Progenitor Cells Continues to Fall Short of the Promise

被引:21
作者
Deb, Arjun [1 ,4 ]
Patterson, Cam [1 ,2 ,3 ]
机构
[1] Univ N Carolina, McAllister Heart Inst, Dept Med, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, McAllister Heart Inst, Dept Pharmacol, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, McAllister Heart Inst, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, McAllister Heart Inst, Dept Cellular & Mol Physiol, Chapel Hill, NC 27599 USA
关键词
Editorials; angiogenesis; atherosclerosis; endothelium; BONE-MARROW; ATHEROSCLEROSIS;
D O I
10.1161/CIR.0b013e3181d4c360
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:850 / 852
页数:3
相关论文
共 12 条
[1]   Isolation of putative progenitor endothelial cells for angiogenesis [J].
Asahara, T ;
Murohara, T ;
Sullivan, A ;
Silver, M ;
vanderZee, R ;
Li, T ;
Witzenbichler, B ;
Schatteman, G ;
Isner, JM .
SCIENCE, 1997, 275 (5302) :964-967
[2]   Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines [J].
Fazel, Shafie ;
Cimini, Massimo ;
Chen, Liwen ;
Li, Shuhong ;
Angoulvant, Denis ;
Fedak, Paul ;
Verma, Subodh ;
Weisel, Richard D. ;
Keating, Armand ;
Li, Ren-Ke .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (07) :1865-1877
[3]   Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy [J].
Gnecchi, Massimiliano ;
Zhang, Zhiping ;
Ni, Aiguo ;
Dzau, Victor J. .
CIRCULATION RESEARCH, 2008, 103 (11) :1204-1219
[4]   Circulating Endothelial Progenitor Cells Do Not Contribute to Plaque Endothelium in Murine Atherosclerosis [J].
Hagensen, Mette K. ;
Shim, Jeong ;
Thim, Troels ;
Falk, Erling ;
Bentzon, Jacob F. .
CIRCULATION, 2010, 121 (07) :898-905
[5]   Circulating endothelial progenitor cells, vascular function, and cardiovascular risk [J].
Hill, JM ;
Zalos, G ;
Halcox, JPJ ;
Schenke, WH ;
Waclawiw, MA ;
Quyyumi, AA ;
Finkel, T .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (07) :593-600
[6]   Assessing identity, phenotype, and fate of endothelial progenitor cells [J].
Hirschi, Karen K. ;
Ingram, David A. ;
Yoder, Mervin C. .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (09) :1584-1595
[7]   Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells [J].
Ingram, DA ;
Caplice, NM ;
Yoder, MC .
BLOOD, 2005, 106 (05) :1525-1531
[8]   Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart [J].
Minami, E ;
Laflamme, MA ;
Saffitz, JE ;
Murry, CE .
CIRCULATION, 2005, 112 (19) :2951-2958
[9]   Aging, progenitor cell exhaustion, and atherosclerosis [J].
Rauscher, FM ;
Goldschmidt-Clermont, PJ ;
Davis, BH ;
Tang, W ;
Gregg, D ;
Ramaswami, R ;
Pippen, AM ;
Annex, BH ;
Dong, CM ;
Taylor, DA .
CIRCULATION, 2003, 108 (04) :457-463
[10]   Transplantation of bone marrow-derived mononuclear cells in ischemic apolipoprotein E-knockout mice accelerates atherosclerosis without altering plaque composition [J].
Silvestre, JS ;
Gojova, A ;
Brun, V ;
Potteaux, S ;
Esposito, B ;
Duriez, M ;
Clergue, M ;
Le Ricousse-Roussanne, S ;
Barateau, V ;
Merval, R ;
Groux, H ;
Tobelem, G ;
Levy, B ;
Tedgui, A ;
Mallat, Z .
CIRCULATION, 2003, 108 (23) :2839-2842