Genetic Structure of the Spanish Population

被引：45

作者：

Gayan, Javier ^{[1
]}

Galan, Jose J. ^{[1
]}

Gonzalez-Perez, Antonio ^{[1
]}

Eugenia Saez, Maria ^{[1
]}

Teresa Martinez-Larrad, Maria ^{[2
]}

Zabena, Carina ^{[2
]}

Carmen Rivero, M. ^{[1
]}

Salinas, Ana ^{[1
]}

Ramirez-Lorca, Reposo ^{[1
]}

Moron, Francisco J. ^{[1
]}

Luis Royo, Jose ^{[1
]}

Moreno-Rey, Concha ^{[1
]}

Velasco, Juan ^{[1
]}

Carrasco, Jose M. ^{[1
]}

Molero, Eva ^{[1
]}

Ochoa, Carolina ^{[1
]}

Dolores Ochoa, Maria ^{[1
]}

Gutierrez, Marta ^{[1
]}

Reina, Mercedes ^{[1
]}

Pascual, Rocio ^{[1
]}

Romo-Astorga, Alejandro ^{[1
]}

Luis Susillo-Gonzalez, Juan ^{[1
]}

Vazquez, Enrique ^{[1
]}

Real, Luis M. ^{[1
]}

Ruiz, Agustin ^{[1
]}

Serrano-Rios, Manuel ^{[2
]}

机构：

[1] Neocodex, Dept Struct Genom, Seville, Spain

[2] Hosp Clin San Carlos, Dept Internal Med 2, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain

来源：

BMC GENOMICS | 2010年 / 11卷

关键词：

COPY-NUMBER VARIATIONS; HUMAN GENOME; EUROPEAN POPULATIONS; HAPLOTYPE MAP; ASSOCIATION; PREVALENCE; DISEASE;

D O I：

10.1186/1471-2164-11-326

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background: Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. Results: In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts. Conclusions: In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.

引用

页数：15

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