The lymphotoxin Cys13Arg polymorphism and cognitive functioning in individuals with schizophrenia

被引：10

作者：

Dickerson, Faith

Boronow, John

Stallings, Cassie

Origoni, Andrea

Yolken, Robert

机构：

[1] Stanley Res Ctr Sheppard Pratt, Baltimore, MD 21204 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat, Stanley Neurovirol Lab, Baltimore, MD 21207 USA

来源：

SCHIZOPHRENIA RESEARCH | 2007年 / 89卷 / 1-3期

关键词：

schizophrenia; immune response; cognitive functioning; genetic;

D O I：

10.1016/j.schres.2006.08.015

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Genetic factors that modulate the immune response have been implicated as risk factors for schizophrenia and cognitive impairment. We assessed the correlation between cognitive functioning and the LTA Cys13Arg polymorphism in 351 individuals with schizophrenia, 122 with bipolar disorder, and 160 controls. There was a significant association between cognitive functioning and the LTA Cys13Arg polymorphism within the schizophrenia (p < 0.008) but not the other diagnostic groups. There was no association between cognitive functioning and the two other polymorphisms in the same gene complex. The LTA Cys13Arg polymorphism may represent a risk factor for cognitive impairment in individuals with schizophrenia. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：173 / 176

页数：4

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