The cytotoxicity of CdTe quantum dots and the relative contributions from released cadmium ions and nanoparticle properties

被引：277

作者：

Su, Yuanyuan ^{[1
,2
]}

Hu, Mei ^{[1
,3
]}

Fan, Chunhai ^{[1
]}

He, Yao ^{[4
]}

Li, Qingnuan ^{[1
]}

Li, Wenxin ^{[1
]}

Wang, Lian-hui ^{[3
]}

Shen, Pingping ^{[2
]}

Huang, Qing ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Appl Phys, Phys Biol Lab, Shanghai 201800, Peoples R China

[2] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[3] Fudan Univ, LAM, Shanghai 200433, Peoples R China

[4] Soochow Univ, Funct Nano & Soft Mat Lab FUNSOM, Suzhou 215123, Jiangsu, Peoples R China

来源：

BIOMATERIALS | 2010年 / 31卷 / 18期

基金：

美国国家科学基金会;

关键词：

Quantum dots; Cytotoxicity; Nanomaterials; IN-VIVO; GOLD NANOPARTICLES; CELLS; NANOCRYSTALS; PROBES; CDSE; NANOTECHNOLOGY; DELIVERY; DNA;

D O I：

10.1016/j.biomaterials.2010.02.074

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A systematic study was carried out on the relationship between the cytotoxicity of quantum dots (QDs) and free cadmium ions using CdCl2 solution with known amounts of Cd2+ as the control. We found that the CdTe QDs were more cytotoxic than CdCl2 solutions even when the intracellular Cd2+ concentrations were identical in HEK293 cells treated with them, implying the cytotoxicity of CdTe QDs cannot attributed solely to the toxic effect of free Cd2+. Moreover, we discovered that the cytotoxicity of QDs was based on the concentration of total QDs ingested by cells. Our data clearly showed that specific properties of nanopartices have an obvious influence on their cytotoxicity. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4829 / 4834

页数：6

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