Continuous enteral nutrition attenuates pulmonary edema in rats exposed to 100% oxygen

被引:11
作者
Factor, P
Ridge, K
Alverdy, J
Sznajder, JI
机构
[1] Evanston NW Healthcare, Evanston, IL 60201 USA
[2] Northwestern Univ, Sch Med, Chicago, IL 60611 USA
[3] Univ Chicago, Dept Surg, Chicago, IL 60616 USA
关键词
sodium-potassium-adenosine 5 '-triphosphatase; glutathione peroxidase; hyperoxia;
D O I
10.1152/jappl.2000.89.5.1759
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Adult rats exposed to hyperoxia develop anorexia, weight loss, and a lung injury characterized by pulmonary edema and decreased lung liquid clearance. We hypothesized that maintenance of nutrition during hyperoxia could attenuate hyperoxia-induced pulmonary edema. To test this hypothesis, we enterally fed adult male Sprague-Dawley rats via gastrostomy tubes and exposed them to oxygen (inspired O-2 fraction >0.95) for 64 h. In contrast to controls, enterally fed hyperoxic animals did not lose weight and had smaller pleural effusions and wet-to-dry weight ratios (a measure of lung edema) that were not different from room air controls. Enterally fed rats exposed to hyperoxia had increased levels of mRNA for the Na+-K+ ATPase alpha (1)- and beta (1)-subunits and glutathione peroxidase. These findings suggest that maintenance of nutrition during an oxidative lung injury reduces lung edema, perhaps by allowing for continued expression and function of protective proteins such as the Na+-K+-ATPase.
引用
收藏
页码:1759 / 1765
页数:7
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