Developmental expression of the estrogen receptor-related receptor γ in the nervous system during mouse embryogenesis

被引：34

作者：

Hermans-Borgmeyer, I ^{[1
]}

Süsens, U ^{[1
]}

Borgmeyer, U ^{[1
]}

机构：

[1] Univ Hamburg, Inst Entwicklungsneurobiol, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 97卷 / 1-2期

关键词：

orphan nuclear receptor; estrogen receptor-related receptor; expression pattern; mouse embryogenesis; in situ hybridization; nervous system;

D O I：

10.1016/S0925-4773(00)00422-6

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ERR's (estrogen receptor-related receptors) are constitutive activators of the classical estrogen response element. In this report, we demonstrate that ERR gamma is highly expressed in the nervous system of the developing mouse embryo and that the adult pattern of expression of ERR gamma is, with few exceptions, established during embryogenesis. Transcripts are preferentially detected in already differentiating areas of the nervous system. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：197 / 199

页数：3

共 9 条

[1] Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR [J].

Chen, F ;

Zhang, Q ;

McDonald, T ;

Davidoff, MJ ;

Wendy, B ;

Bai, C ;

Liu, QY ;

Caskey, CT .

GENE, 1999, 228 (1-2) :101-109

[2] Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of usher syndrome type IIa at 1q41 [J].

Eudy, JD ;

Yao, SF ;

Weston, MD ;

Ma-Edmonds, M ;

Talmadge, CB ;

Cheng, JJ ;

Kimberling, WJ ;

Sumegi, J .

GENOMICS, 1998, 50 (03) :382-384

[3] Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3 [J].

Hong, H ;

Yang, L ;

Stallcup, MR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (32) :22618-22626

[4]

Kaufman M. H., 1992, Atlas of mouse development

[5] Differential expression of the estrogen receptor-related receptor γ in the mouse brain [J].

Lorke, DE ;

Süsens, U ;

Borgmeyer, U ;

Hermans-Borgmeyer, I .

MOLECULAR BRAIN RESEARCH, 2000, 77 (02) :277-280

[6]

Nagase T, 1998, DNA Res, V5, P355, DOI 10.1093/dnares/5.6.355

[7]

Rugh, 1990, MOUSE ITS REPROD DEV

[8] Alternative splicing and expression of the mouse estrogen receptor-related receptor γ [J].

Süsens, U ;

Hermans-Borgmeyer, I ;

Borgmeyer, U .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 267 (02) :532-535

[9] The germ cell nuclear factor mGCNF is expressed in the developing nervous system [J].

Susens, U ;

Aguiluz, JB ;

Evans, RM ;

Borgmeyer, U .

DEVELOPMENTAL NEUROSCIENCE, 1997, 19 (05) :410-420

← 1 →