Differential expression of the estrogen receptor-related receptor γ in the mouse brain

被引：43

作者：

Lorke, DE

Süsens, U

Borgmeyer, U

Hermans-Borgmeyer, I

机构：

[1] Univ Hamburg, Krankenhaus Eppendorf, Inst Entwicklungsneurobiol, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany

[2] Univ Hamburg, Krankenhaus Eppendorf, Abt Neuroanat, D-20246 Hamburg, Germany

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 77卷 / 02期

关键词：

orphan nuclear receptor; expression; in situ hybridization;

D O I：

10.1016/S0169-328X(00)00063-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To elucidate estrogen functions, the expression of the estrogen receptor-related receptor ERR gamma, a novel orphan nuclear receptor regulating transcription via estrogen responsive elements, has been localized by in situ hybridization in adult murine brain. ERR gamma transcripts were abundantly present in the isocortex, the olfactory system, cranial nerve nuclei and major parts of the coordination centers, e.g. reticular formation and major parts of the extrapyramidal motor systems. In addition, ERR gamma expression was detected in trigeminal ganglion neurons. ERR gamma distribution was clearly distinguished from that described fur ERR alpha, for ERR beta, and for estrogen receptors (ER) pointing at functional differences between ERR gamma and these receptors. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：277 / 280

页数：4

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