RNA turnover in human mitochondria: More questions than answers?

被引：36

作者：

Borowski, Lukasz S. ^{[1
]}

Szczesny, Roman J. ^{[1
,2
]}

Brzezniak, Lien K. ^{[1
]}

Stepien, Piotr P. ^{[1
,2
]}

机构：

[1] Warsaw Univ, Fac Biol, Inst Genet & Biotechnol, PL-02106 Warsaw, Poland

[2] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2010年 / 1797卷 / 6-7期

关键词：

Mitochondrion; RNA degradation; RNA surveillance; Polynucleotide phosphorylase (PNPase); Poly(A) polymerase (PAP); Suv3; helicase; (SUPV3L1; hSuv3p); HUMAN POLYNUCLEOTIDE PHOSPHORYLASE; MESSENGER-RNA; POLY(A) POLYMERASE; RNA/DNA HELICASE; SACCHAROMYCES-CEREVISIAE; HSUV3P HELICASE; 3' ENDS; POLYADENYLATION; DEGRADATION; GENE;

D O I：

10.1016/j.bbabio.2010.01.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein complexes responsible for RNA degradation play important role in three key aspects of RNA metabolism: they control stability of physiologically functional transcripts, remove the unnecessary RNA processing intermediates and destroy aberrantly formed RNAs. In mitochondria the post-transcriptional events seem to play a major role in regulation of gene expression, therefore RNA turnover is of particular importance. Despite many years of research, the details of this process are still a challenge. This review summarizes emerging landscape of interplay between the Suv3p helicase (SUPV3L1, Suv3), poly(A) polymerase and polynucleotide phosphorylase in controlling RNA degradation in human mitochondria. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1066 / 1070

页数：5

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